Diastole em detalhes

(Circulation. 2008;117:2051-2060.)

Heart Failure
Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction
Dirk Westermann, MD; Mario Kasner, MD; Paul Steendijk, PhD; Frank Spillmann, MD; Alexander Riad, MD; Kerstin Weitmann, MSc; Wolfgang Hoffmann, MD, MPH; Wolfgang Poller, MD; Matthias Pauschinger, MD; Heinz-Peter Schultheiss, MD; Carsten Tschöpe, MD

Using direct invasive measurements, we have shown that diastolic abnormalities with increased diastolic stiffness lead to a reduced stroke volume during pacing-induced tachycardia and an increase in EDP during handgrip exercise. We therefore propose that increased diastolic stiffness significantly modulates the clinical symptoms in patients with HFNEF. A reduction in diastolic stiffness is one of the targets for treating HFNEF.