Pressão pulmonar na Estenose Aórtica pela relação E/Ea

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E/Ea is the Major Determinant of Pulmonary Artery Pressure in Moderate to Severe Aortic Stenosis
Casaclang-Verzosa, Grace MD; Nkomo, Vuyisile T. MD; Sarano, Maurice E. MD; Malouf, Joseph F. MD; Miller, Fletcher A. Jr MD; Oh, Jae K. MD
JASE Volume 21(7), July 2008, p 824–827
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E/Ea ratio was the only independent predictor of PASP after adjusting for the other variables. AVA did not correlate with diastolic dysfunction or filling pressure. Thus, despite a critically stenosed aortic valve, PHT was not always observed.
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Hence, if PHT cannot be explained by the severity of AS, superimposed diastolic dysfunction should be considered and evaluated. If filling pressure is increased and AS is less than severe in patients with dyspnea, medical therapy to reduce diastolic filling pressure may be tried before aortic valve replacement. Therefore, evaluation of diastolic function should be an integral part of the echocardiographic examination when assessing patients with AS. The presence of PHT also should alert physicians to the possibility of superimposed diastolic dysfunction in patients with AS.
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Conclusion:: Our findings suggest that in moderate to severe AS, diastolic function, not AS severity, determines PASP. Superimposed diastolic dysfunction likely contributes to clinical symptoms of moderate to severe AS.
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