Rapid Detection of Coronary Artery Stenoses with Real Time Perfusion Echocardiography During Regadenoson Stress
Methods and Results—In 100 patients referred for quantitative coronary angiography (QCA), RTMCE was performed during a continuous intravenous infusion of 3% Definity (Lantheus Medical Imaging) at baseline and at two minute intervals for up to six minutes following a regadenoson bolus injection (400 ug). Myocardial perfusion was assessed by examining myocardial contrast replenishment (MCR) following brief high mechanical index impulses. A perfusion defect was defined as a delay (>2 seconds) in MCR in two contiguous segments. Wall motion (WM) was also analyzed. The overall sensitivity/specificity/accuracy for myocardial perfusion analysis in detecting a >50% diameter stenosis was 80%/74%/78%, while for WM analysis it was 60%/72%/66% (p<0.001 for differences in sensitivity). Sensitivity for myocardial perfusion analysis was highest on images obtained during the first two minutes following regadenoson bolus (p<0.001 compared to wall motion), while wall motion sensitivity was highest at the 4-6 minute period following the bolus.No significant side effects occurred following regadenoson bolus injection.
Precisaram inventar uma nova adenosina, colocar o T. Porter para trabalhar, usar as instalações do University of Nebraska Medical Center, para provar que:
- O Morcerf SEMPRE esteve certo ao usa um vasodilatador em bolus com as microbolhas para demonstrar defeitos de perfusão!. Nós fizemos 300 exames com o método e Definity , só paramos por falta de microbolhas!