Real-Time 3D Echocardiographic Quantification of Left Atrial VolumeMulticenter Study for Validation.LINK.
Results 3DE-derived LAV values showed higher correlation
with CMR than 2DE measurements (r = 0.93 vs. r = 0.74 for maximal LAV; r = 0.88
vs. r = 0.82 for minimal LAV). Although 2DE underestimated maximal LAV by 31 ±
25 ml and minimal LAV by 16 ± 32 ml, 3DE resulted in a minimal bias of −1 ± 14
ml for maximal LAV and 0 ± 21 ml for minimal LAV. Interobserver and
intraobserver variability of 2DE and 3DE measurements of maximal LAV were
similar (7% to 12%) and approximately 2 times higher than CMR (4% to 5%). 3DE
classified enlarged atria more accurately than 2DE (kappa: 0.88 vs. 0.71).
Conclusions Compared with CMR reference, 3DE-derived LAV
measurements are more accurate than 2DE-based analysis, resulting in fewer
patients with undetected atrial enlargement.