sexta-feira, julho 01, 2011
Mais cálcio que macrófagos
High-Sensitivity C-Reactive Protein, Vascular Imaging, and Vulnerable Plaque: More Evidence to Support Trials of Antiinflammatory Therapy for Cardiovascular Risk Reduction
Circulation: Cardiovascular Imaging
Issue: Volume 4(3), May 2011, p 195–197
As anticipated, patients with elevated hsCRP levels had a higher prevalence of smoking, hypertension, diabetes, and hyperlipidemia. What is intriguing, however, is the manner in which hsCRP levels correlate with underlying plaque morphology as defined by CCTA. Specifically, although higher hsCRP levels were found to associate with greater total plaque burden, these associations were only significant for noncalcified and mixed-calcified plaques. By contrast, there was little if any evidence of association between hsCRP levels and fully calcified plaques. Further, the association of hsCRP level to noncalcified plaques was substantial: Compared to patients with low hsCRP levels, patients with elevated levels had a doubling of risk for noncalcified plaques after adjustment for age and sex. Thus, as seen in earlier histopathology studies and in evaluations of sudden cardiac death, the present CCTA-based study affirms that hsCRP level associates with vulnerable plaque.
Estudo mostrou correlação forte de inflamação com placas moles ou mixtas. As placas duras e calcificadas, não se correlacioram com inflamação e o Cálcio elevado na placa.
As vezes é preciso que o próprio método caia em contradição, para comprovar que a fisiopatologia nunca está errada. Estamos em busca do paciente vulnerável a eventos indesejados. Então devemos usar métodos de pesquisa de vulnarebilidade dinâmicos!