sexta-feira, agosto 13, 2010
Chagas, Minas e o European Echocardiography
Functional capacity and right ventricular function in patients with Chagas heart disease
Maria do Carmo Pereira Nunes, Francilu R. Beloti, Marcia Maria Oliveira Lima, Marcia M. Barbosa, Marcelo Martins Pinto Filho, Marcio Vinícius Lins de Barros and Manoel O.C. Rocha.
Methods and results We evaluated 65 patients (48.6 ± 9.1 years, 60% men) with Chagas heart disease. Standard and tissue Doppler echocardiography were performed before maximal exercise testing. Tissue Doppler imaging (TDI) was used to measure RV peak annular systolic and diastolic velocities. Exercise testing was performed using a standard Bruce protocol. Linear regression analysis was used to determine multivariate peak oxygen consumption (VO2) predictors. All patients were in NYHA functional class I or II. Mean peak VO2 was 32.4 ± 10.2 mL/kg/min and mean LV ejection fraction was 43 ± 11%. There was correlation between TDI RV peak systolic velocity and LV ejection fraction (r = 0.5; P < 0.001). In a multivariate analysis, after adjustment for age and gender, RV function emerged as an independent predictor of functional capacity, as demonstrated in the model: peak VO2 (r = 0.71) was: 42.22−(9.77 × female gender)−(0.29 × age) + (1.54 × RV systolic velocity).
Conclusion In this cross-sectional study, RV function was an important, independent determinant of exercise capacity in patients with Chagas heart disease. TDI RV systolic annular velocity was most closely associated with peak VO2, regardless of the influence of age, gender, and other echocardiographic parameters
Belo estudo de Minas com informações originais. Parabéns ao grupo.