Microcirculação coronária

Coronary microcirculatory vasodilator function in relation to risk factors among patients without obstructive coronary disease and low to intermediate Framingham score
Eur Heart J (2010) 31 (8): 936-942
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Multivariable analysis identified a higher Framingham risk score (P < 0.001), female sex (P < 0.001) and a positive family history of coronary disease (P = 0.043) as independent predictors of reduced CFR(coronary flow reserve).
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Conclusion In patients without obstructive coronary disease, a higher FRS was an independent predictor of reduced CFR. The current study provides insight into the relation between cardiac risk profile and coronary microcirculatory function, and suggests that impaired microcirculatory vasodilator function may be present even in patients with a low to intermediate Framingham score.
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Notem que o Escore era baixo, em torno de 5% de risco em 10 anos e na ausência de coronariopatia obstrutiva relevante. Vejam no gráfico a queda da reserva coronária com o aumento do Escore. A reserva coronária é a primeira a ser reduzida, nos estágios iniciais da Aterosclerose. Estudo muito bom, vale a pena ler e está com acesso livre.